Profhilo® STRUCTURA: Next-Generation Injectable for Facial Volume Restoration

Profhilo® STRUCTURA is the latest evolution in hyaluronic acid injectable treatments, engineered to restore facial volume, enhance contour, and stimulate natural collagen and elastin production. Unlike traditional dermal fillers, this bio-remodeling therapy targets both the superficial and deep layers of the skin, offering long-lasting, natural-looking results with minimal downtime.

Close-up of a smiling woman with clear skin, touching her ear, with water bubbles floating around her.
Box of Profhilo Structure, a skin bioremodeling treatment, with a syringe in front of the box.

Profhilo® STRUCTURA.

Profhilo® STRUCTURA.

What Is Profhilo Structura?

Profhilo Structura is an injectable concentrate of high- and low-molecular-weight hyaluronic acid. Developed by IBSA Pharma, it uses proprietary NAHYCO® Hybrid Technology, which blends hyaluronic acid chains without chemical cross-links. This unique formula:

  • Delivers deep hydration to restore skin elasticity

  • Replenishes diminishing adipose tissue for a subtle lift

  • Triggers fibroblast activity for renewed collagen and elastin

How Profhilo Structura Works

  1. Targeted Injection: Using a micro-bolus technique, tiny aliquots are administered into the superficial fat layer at specific facial points.

  2. Bio-Remodeling Effect: The hyaluronic acid diffuses evenly, remodeling the skin’s architecture and soft tissue.

  3. Stimulation of Skin-Rejuvenating Cells: Fibroblasts and adipocytes are activated, promoting sustainable collagen and elastin synthesis.

Over 4–6 weeks, patients notice improved skin texture, reduced fine lines, and enhanced facial contours.

A woman with smooth skin and dark hair smiling gently, promoting Phi-Nominal Structura treatment at Phi Clinic for rejuvenation and skin architechture.

Key Ingredients and Technology

  1. 45 mg High-Molecular-Weight HA: Provides structural support and immediate volumizing.

  2. 45 mg Low-Molecular-Weight HA: Enhances hydration and bio-integration.

  3. NAHYCO® Hybrid Technology: Ensures a stable, uniform gel that spreads naturally without rigid cross-links.

NAHYCO logo with the text 'NAHYCO Hybrid Technology' and a graphic of three overlapping circles in a cloud shape.

Benefits of Profhilo Structura

Natural-Looking Volume Restoration: Repositions subtle fat loss rather than overfilling.

  1. Improved Skin Hydration: Delivers moisture deep into the dermis for a lasting glow.

  2. Enhanced Skin Elasticity: Boosts firmness, reducing sagging and crepe-like texture.

  3. Minimal Downtime: Quick procedure (30–45 minutes) with only mild swelling or redness.

  4. Long-Lasting Results: Effects typically last 6–9 months, depending on individual metabolism.

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Treatment Areas and Ideal Candidates

Profhilo Structura is indicated for adults aged 30+ experiencing early to advanced signs of facial ageing, including:

  • Mid-face volume loss (cheeks, nasolabial folds)

  • Hollow temples and under-eye hollows

  • Jawline laxity and jowling

  • Fine lines and dehydration

This treatment is especially suited for those seeking subtle facial contouring without the stiffness of traditional dermal fillers.